The Tua Line was inaugurated on 29 September 1887 at a ceremony attended by King Louis I and Queen Maria Pia of Savoy. Its construction was driven by the entrepreneurial vision of Clement Menéres, a man who believed in the economic potential of Trás-os-Montes.

The Mirandela railway station, designed by engineer José Beça, is an imposing building that reflects the importance that the railway had for the region.

In 2024, Mirandela railway station reopens its doors to the public as a venue for arts and culture.