The foundation of the Santa Casa da Misericórdia (portuguese charity) of Bragança dates back to the year 1518 and was “founded in a church that had dedicated to the Holy Spirit” (that gave name to the street). The temple was rebuilt in 1539, to serve as church of the Santa Casa. At the end of the 17th century, the main altar would be endowed with a valuable Mannerist altarpiece (as the central figure Virgin of Mercy.) In an annexed chapel, one can admire a beautiful image of Senhor dos Passos, from the 18th century. The tiles on the front are from the second half of the 19th century.